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1 H NMR (500 MHz, CDCl 3 ) δ 7.88–7.67 (m, 16H, NH and ArH × 15), 7.61 (s, 1H, N H H), 5.88 (s, 1H, NH H ), 3.62–3.53 (m, 2H, H 2 -7), 3.46 (s, 2H), 3.40 (s, 2H), 3.24 (dd, J = 12.0, 6.0 Hz, 2H, H 2 -3), 1.81–1.61 (m, 6H, H 2 -4, H 2 -5 and H 2 -6)

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Several studies have shown that injections dissolved in saline are less painful than those dissolved in water because the body’s natural salinity more closely matches that of saline, eliminating the need to equalize salinity levels