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Common symptoms of Herxheimer reactions include: fever chills feeling cold or shivering nausea and vomiting headache rapid heart rate low blood pressure hyperventilating, muscle pain skin rashes flushing Currently, doctors don’t fully understand how a Herxheimer reaction works and believe it may have several causes

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Diagnosis of endocrine irAEs is often delayed due to the subtle nature of signs and symptoms that often overlap with symptoms typically experienced by patients with advanced cancer, including vomiting, headache, nausea and fatigue